![]() Moreover, JGF may be applicable as an adjuvant preventive strategy against SARS-CoV-2 infection in addition to the use of vaccines. Together, these findings suggest that JGF may improve the COVID-19 like symptoms and inhibit viral infection. Mice that inhale JGF exhibit reduced ACE2 and TMPRSS2 protein levels in lung tissues. Mechanistically, JGF induces lysosomal-dependent ACE2 degradation and suppresses mRNA and the protein levels of TMPRSS2 in human lung WI-38 and MRC-5 cells. Functional studies show that JGF inhibits the formation of syncytium and reduces the formation of viral plaque. This study produces a traditional Chinese medicine formula, Jing Guan Fang (JGF), based on ancient medical texts, and examines the efficacy and the mechanism by which JGF prevents viral infections. Developing adjuvant therapies which could prevent the virus from binding to cells may impair viral infection. ![]() Program, National Yang Ming Chiao Tung University, Taipei, TaiwanĬOVID-19 is a global epidemic. 5Branch of Linsen Chinese and Kunming, Taipei City Hospital, Taipei, Taiwan.4National Research Institute of Chinese Medicine, Taipei, Taiwan.3Institute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.2Institute of Biophotonics, National Yang Ming Chiao Tung University, Taipei, Taiwan.1Department and Institute of Pharmacology, National Yang Ming Chiao Tung University, Taipei, Taiwan.Yueh-Hsin Ping 1,2, Hsin Yeh 3, Li-Wei Chu 1, Zhi-Hu Lin 3, Yin-Chieh Hsu 3, Lie-Chwen Lin 4, Chung-Hua Hsu 1,3,5, Shu-Ling Fu 3 * and Tung-Yi Lin 3,6 * ![]()
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